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Thyroid cancer - medullary carcinoma

Thyroid - medullary carcinoma; Cancer - thyroid (medullary carcinoma); MTC; Thyroid nodule - medullary

Medullary carcinoma of the thyroid is cancer of the thyroid gland that starts in cells that release a hormone called calcitonin. These cells are called "C" cells. The thyroid gland is located inside the front of your lower neck.

Causes

The cause of medullary carcinoma of the thyroid (MTC) is unknown. MTC is very rare. It can occur in children and adults.

Unlike other types of thyroid cancer, MTC is less likely to be caused by radiation therapy to the neck given to treat other cancers during childhood.

There are two forms of MTC:

  • Sporadic MTC, which does not run in families. Most MTCs are sporadic. This form mainly affects older adults.
  • Inherited MTC, which runs in families.

You have an increased risk for this type of cancer if you have:

Other types of thyroid cancer include:

Symptoms

MTC often begins as a small lump (nodule) in the thyroid gland. There may also be lymph node swelling in the neck. As a result, symptoms may include:

  • Swelling of the neck
  • Hoarseness
  • Breathing problems due to narrowing of airways
  • Cough
  • Cough with blood
  • Diarrhea due to high calcitonin level

Exams and Tests

Your health care provider will perform a physical exam and ask about your symptoms and medical history.

Tests that may be used to diagnose MTC include:

People with MTC should be checked for certain other tumors, especially pheochromocytoma.

Treatment

Treatment involves surgery to remove the thyroid gland and surrounding lymph nodes. Because this is an uncommon tumor, surgery should be performed by a surgeon who is familiar with this type of cancer and experienced with the operation required.

Chemotherapy and radiation do not work very well for this type of cancer. Radiation is used in some people after surgery. New treatments are being investigated in clinical trials. Your provider can tell you more about these, if needed.

Support Groups

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

Outlook (Prognosis)

People with medullary carcinoma of the thyroid live at least 5 years after diagnosis, depending upon the stage of the cancer. Women have better prognosis than men. The 10 year survival rate is 75%.

Possible Complications

Complications may include:

  • Cancer spreads to other areas of the body
  • Parathyroid glands are accidentally removed during surgery

When to Contact a Medical Professional

Call your provider if you have symptoms of medullary carcinoma of the thyroid.

Prevention

Prevention may not be possible. But, being aware of your risk factors, especially your family history, may allow for early diagnosis and treatment. For people who have a very strong family history of MTC, the option to remove the thyroid gland may be recommended. You should carefully discuss this option with a doctor who is very familiar with the disease.

References

National Cancer Institute website. Thyroid cancer treatment (adult) (PDQ) - health professional version. www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq. Updated February 1, 2018. Accessed March 22, 2018.

Smith PW, Hanks LR, Salomone LJ, Hanks JB. Thyroid. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 20th ed. Philadelphia, PA: Elsevier Saunders; 2017:chap 36.

Wells SA. Medullary thyroid carcinoma. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 246.

    • Thyroid cancer - CT scan

      Thyroid cancer - CT scan - illustration

      This CT scan of the upper chest (thorax) shows a malignant thyroid tumor (cancer). The dark area around the trachea (marked by the white U-shaped tip of the respiratory tube) is an area where normal tissue has been eroded and died (necrosis) as a result of tumor growth.

      Thyroid cancer - CT scan

      illustration

    • Thyroid gland

      Thyroid gland - illustration

      The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.

      Thyroid gland

      illustration

      • Thyroid cancer - CT scan

        Thyroid cancer - CT scan - illustration

        This CT scan of the upper chest (thorax) shows a malignant thyroid tumor (cancer). The dark area around the trachea (marked by the white U-shaped tip of the respiratory tube) is an area where normal tissue has been eroded and died (necrosis) as a result of tumor growth.

        Thyroid cancer - CT scan

        illustration

      • Thyroid gland

        Thyroid gland - illustration

        The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.

        Thyroid gland

        illustration

      Review Date: 1/19/2018

      Reviewed By: Richard LoCicero, MD, private practice specializing in hematology and medical oncology, Longstreet Cancer Center, Gainesville, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

      The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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