Post-splenectomy syndromeSplenectomy - post-surgery syndrome; Overwhelming post-splenectomy infection; OPSI; Splenectomy - reactive thrombocytosis
Post-splenectomy syndrome can occur after surgery to remove the spleen. It consists of a group of symptoms and signs such as:
- Blood clots
- Destruction of red blood cells
- Increased risk for severe infections from bacteria such as Streptococcus pneumoniae and Neisseria meningitidis
- Thrombocytosis (increased platelet count, which can cause blood clots)
A platelet count is a lab test to measure how many platelets you have in your blood. Platelets are parts of the blood that helps the blood clot. Th...Read Article Now Book Mark Article
Possible long-term medical problems include:
- Hardening of the arteries (atherosclerosis)
- Pulmonary hypertension (a disease affecting the blood vessels in your lungs)
Connell NT, Shurin SB, Schiffman F. The spleen and its disorders. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 160.
Poulose BK, Holzman MD. The spleen. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 20th ed. Philadelphia, PA: Elsevier; 2017:chap 56.
Spleen - illustration
The spleen is an organ involved in the production and maintenance of red blood cells, the production of certain circulating white blood cells, as a part of the lymph system, and as a part of the immune system.
Review Date: 1/29/2019
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.