Ham testAcid hemolysin test; Paroxysmal nocturnal hemoglobinuria - Ham test; PNH - Ham test
The Ham test is a blood test to diagnose paroxysmal nocturnal hemoglobinuria (PNH). This rare condition causes red blood cells to die before they should. The Ham test checks whether red blood cells become more fragile when they are placed in mild acid.
Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria is a rare disease in which red blood cells break down earlier than normal.
Today, the Ham test has been replaced by a test that uses flow cytometry to diagnose PNH.
Brodsky RA. Paroxysmal nocturnal hemoglobinuria. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 31.
Review Date: 2/6/2020
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.