Antiphospholipid syndrome - APSAnticardiolipin antibodies; Hughes syndrome
Antiphospholipid syndrome (APS) is an autoimmune disorder that involves frequent blood clots (thromboses). When you have this condition, your body's immune system makes abnormal proteins that attack the blood cells and lining of the blood vessels. The presence of these antibodies can cause problems with blood flow and lead to dangerous clots in blood vessels throughout the body.
Amigo M-C, Khamashta MA. Antiphospholipid syndrome: pathogenesis, diagnosis, and management. In: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 148.
Cervera R, Rodríguez-Pintó I, Colafrancesco S, et al. 14th International Congress on Antiphospholipid Antibodies Task Force report on catastrophic antiphospholipid syndrome. Autoimmun Rev. 2014;13(7):699-707. PMID: 24657970 www.ncbi.nlm.nih.gov/pubmed/24657970.
Dufrost V, Risse J, Wahl D, Zuily S. Direct oral anticoagulants use in antiphospholipid syndrome: are these drugs an effective and safe alternative to warfarin? A systematic review of the literature: response to comment. Curr Rheumatol Rep. 2017;19(8):52. PMID: 28741234 www.ncbi.nlm.nih.gov/pubmed/28741234.
Erkan D, Salmon JE, Lockshin MD. Anti-phospholipid syndrome. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley and Firestein's Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017:chap 82.
National Heart, Lung, and Blood Institute website. Antiphospholipid antibody syndrome. www.nhlbi.nih.gov/health-topics/antiphospholipid-antibody-syndrome. Accessed June 5, 2019.